![]() DAAO is expressed in the mammalian brain and periphery. The enzyme D-amino acid oxidase (DAAO) metabolizes D-amino acids, and in particular, metabolizes D-serine in vitro at physiological pH. ![]() R6 and R7 are independently selected from hydrogen and alkyl Īt least one of R1, R2 and R4 is other than hydrogen andĭ-serine or cycloserine may be coadministered along with the compound of formula I. ![]() R5 is selected from aryl, substituted aryl, heteroaryl and substituted heteroaryl ![]() R4 is from selected from hydrogen, halo, nitro, alkyl, alkylaryl, and XYR5 M is aluminum, calcium, lithium, magnesium, potassium, sodium, zinc ion or a mixture thereof X and Y are independently selected from O, S, NH, and (CR6R7)n Or R1 and R2, taken together, form a 5, 6, 7 or 8-membered substituted or unsubstituted carbocyclic or heterocyclic group R1 and R2 are independently selected from hydrogen, halo, nitro, alkyl, acyl, alkylaryl, and XYR5 Methods for increasing D-Serine concentration and reducing concentration of the toxic products of D-Serine oxidation, for enhancing learning, memory and/or cognition, or for treating schizophrenia, Alzheimer's disease, ataxia or neuropathic pain, or preventing loss in neuronal function characteristic of neurodegenerative diseases involve administering to a subject in need of treatment a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or solvate thereof:
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